Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

Abstract As one of the key components in model‐informed drug discovery and development, physiologically‐based pharmacokinetic (PBPK) modeling linked with in vitro‐to‐in vivo extrapolation (IVIVE) is widely applied to quantitatively predict drug-drug interactions (DDIs) on drug‐metabolizing enzymes a...

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Main Authors: Shinji Yamazaki (Author), Raymond Evers (Author), Loeckie De Zwart (Author)
Format: Book
Published: Wiley, 2022-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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