The Compound <i>(E)</i>-2-Cyano-<i>N</i>,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

• Main Authors: Pablo Rayff da Silva (Author), Renan Fernandes do Espírito Santo (Author), Camila de Oliveira Melo (Author), Fábio Emanuel Pachú Cavalcante (Author), Thássia Borges Costa (Author), Yasmim Vilarim Barbosa (Author), Yvnni M. S. de Medeiros e Silva (Author), Natália Ferreira de Sousa (Author), Cristiane Flora Villarreal (Author), Ricardo Olímpio de Moura (Author), Vanda Lucia dos Santos (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The compound <i>(E)</i>-2-cyano-<i>N</i>,3-diphenylacrylamide (JMPR-01) was structurally developed using bioisosteric modifications of a hybrid prototype as formed from fragments of indomethacin and paracetamol. Initially, in vitro assays were performed to determine cell viab...