A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide

• Main Authors: Kaneko Shuji (Author), Kawakami Seiko (Author), Hara Yuji (Author), Wakamori Minoru (Author), Itoh Etsuko (Author), Minami Toshiyuki (Author), Takada Yuki (Author), Kume Toshiaki (Author), Katsuki Hiroshi (Author), Mori Yasuo (Author), Akaike Akinori (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: A brief exposure to hydrogen peroxide (H2O2) induces severe deterioration of primary cultured neurons in vitro. We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR). In cultured cerebral cortical neurons from...