G-Quadruplex Linked DNA Guides Selective Transfection into Nucleolin-Overexpressing Cancer Cells

• Main Authors: Mengxi Xiang (Author), Yongkui Li (Author), Jia Liu (Author), Jie Shi (Author), Yizhi Ge (Author), Chen Peng (Author), Yawen Bin (Author), Zheng Wang (Author), Lin Wang (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene therapy is a promising approach for treating tumors. Conventional approaches of DNA delivery depending on non-viral or viral vectors are unsatisfactory due to the concerns of biosafety and cell-targeting efficiency. The question how to deliver DNA into tumor cells efficiently and selectively is...