Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders

• Main Authors: Payyalot Koyiparambath Vishal (Author), Jong Min Oh (Author), Ahmed Khames (Author), Mohamed A. Abdelgawad (Author), Aathira Sujathan Nair (Author), Lekshmi R. Nath (Author), Nicola Gambacorta (Author), Fulvio Ciriaco (Author), Orazio Nicolotti (Author), Hoon Kim (Author), Bijo Mathew (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Six halogenated trimethoxy chalcone derivatives (CH1-CH6) were synthesized and spectrally characterized. The compounds were further evaluated for their inhibitory potential against monoamine oxidases (MAOs) and β-secretase (BACE-1). Six compounds inhibited MAO-B more effectively than MAO-A, and the...