Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy

• Main Authors: Mayumi Takahashi (Author), Haitang Li (Author), Jiehua Zhou (Author), Pritsana Chomchan (Author), Veenu Aishwarya (Author), Masad J. Damha (Author), John J. Rossi (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently, the most effective and durable therapeutic option for HIV-1 infection is combination antiretroviral therapy (cART). Although cART is powerful and can delay viral evolution of drug resistance for decades, it is associated with limitations, including an inability to eradicate the virus and...