Impact of Matrix Surface Area on Griseofulvin Release from Extrudates Prepared via Nanoextrusion

• Main Authors: Meng Li (Author), Casey Furey (Author), Jeffrey Skros (Author), Olivia Xu (Author), Mahbubur Rahman (Author), Mohammad Azad (Author), Rajesh Dave (Author), Ecevit Bilgili (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We aimed to examine the impact of milling of extrudates prepared via nanoextrusion and the resulting matrix surface area of the particles on griseofulvin (GF, a model poorly soluble drug) release during in vitro dissolution. Wet-milled GF nanosuspensions containing a polymer (Sol: Soluplus<sup>...