Combined Role of Interleukin-15 Stimulated Natural Killer Cell-Derived Extracellular Vesicles and Carboplatin in Osimertinib-Resistant H1975 Lung Cancer Cells with EGFR Mutations

• Hauptverfasser: Aakash Nathani (Verfasst von), Li Sun (Verfasst von), Islauddin Khan (Verfasst von), Mounika Aare (Verfasst von), Arvind Bagde (Verfasst von), Yan Li (Verfasst von), Mandip Singh (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2024-01-01T00:00:00Z.
• Schlagworte: article
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In this study, we evaluated IL-15 stimulated natural killer cell-derived EVs (NK-EVs) as therapeutic agents in vitro and in vivo in Osimertinib-resistant lung cancer (H1975R) with EGFR mutations (L858R) in combination with carboplatin (CBP). NK-EVs were isolated by ultracentrifugation and characteri...