Synthesis, biological activity and molecular modelling studies of shikimic acid derivatives as inhibitors of the shikimate dehydrogenase enzyme of Escherichia coli

• Main Authors: Dulce Catalina Díaz-Quiroz (Author), César Salvador Cardona-Félix (Author), José Luis Viveros-Ceballos (Author), Miguel Angel Reyes-González (Author), Franciso Bolívar (Author), Mario Ordoñez (Author), Adelfo Escalante (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Shikimic acid (SA) pathway is the common route used by bacteria, plants, fungi, algae, and certain Apicomplexa parasites for the biosynthesis of aromatic amino acids and other secondary metabolites. As this essential pathway is absent in mammals designing inhibitors against implied enzymes may lead...