Relation between Plasma Trough Concentration of Pazopanib and Progression-Free Survival in Metastatic Soft Tissue Sarcoma Patients

• Автори: Marie-Sophie (Автор), Pascaline Boudou-Rouquette (Автор), Anne Jouinot (Автор), Sixtine de Percin (Автор), David Balakirouchenane (Автор), Nihel Khoudour (Автор), Camille Tlemsani (Автор), Jonathan Chauvin (Автор), Audrey Thomas-Schoemann (Автор), François Goldwasser (Автор), Benoit Blanchet (Автор), Jérôme Alexandre (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: Pazopanib (PAZ) is an oral angiogenesis inhibitor approved to treat soft tissue sarcoma (STS) but associated with a large interpatient pharmacokinetic (PK) variability and narrow therapeutic index. We aimed to define the specific threshold of PAZ trough concentration (C<sub>min<...