Population Pharmacokinetic Method to Predict Within-Subject Variability Using Single-Period Clinical Data

• Asıl Yazarlar: Won-ho Kang (Yazar), Jae-yeon Lee (Yazar), Jung-woo Chae (Yazar), Kyeong-Ryoon Lee (Yazar), In-hwan Baek (Yazar), Min-Soo Kim (Yazar), Hyun-moon Back (Yazar), Sangkeun Jung (Yazar), Craig Shaffer (Yazar), Rada Savic (Yazar), Hwi-yeol Yun (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2021-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Sample sizes for single-period clinical trials, including pharmacokinetic studies, are statistically determined by within-subject variability (WSV). However, it is difficult to determine WSV without replicate-designed clinical trial data, and statisticians typically estimate optimal sample sizes usi...