Population Pharmacokinetic Method to Predict Within-Subject Variability Using Single-Period Clinical Data

• Hoofdauteurs: Won-ho Kang (Auteur), Jae-yeon Lee (Auteur), Jung-woo Chae (Auteur), Kyeong-Ryoon Lee (Auteur), In-hwan Baek (Auteur), Min-Soo Kim (Auteur), Hyun-moon Back (Auteur), Sangkeun Jung (Auteur), Craig Shaffer (Auteur), Rada Savic (Auteur), Hwi-yeol Yun (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Sample sizes for single-period clinical trials, including pharmacokinetic studies, are statistically determined by within-subject variability (WSV). However, it is difficult to determine WSV without replicate-designed clinical trial data, and statisticians typically estimate optimal sample sizes usi...