Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis

• Main Authors: Ye Feng (Author), Wei-Lin Qiu (Author), Xin-Xin Yu (Author), Yu Zhang (Author), Mao-Yang He (Author), Lin-Chen Li (Author), Li Yang (Author), Weiyi Zhang (Author), Michael Franti (Author), Junqing Ye (Author), Joerg D. Hoeck (Author), Cheng-Ran Xu (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The streptozotocin (STZ) model is widely used in diabetes research. However, the cellular and molecular states of pancreatic endocrine cells in this model remain unclear. This study explored the molecular characteristics of islet cells treated with STZ and re-evaluated β-cell dysfunction...