Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis

• Главные авторы: Ye Feng (Автор), Wei-Lin Qiu (Автор), Xin-Xin Yu (Автор), Yu Zhang (Автор), Mao-Yang He (Автор), Lin-Chen Li (Автор), Li Yang (Автор), Weiyi Zhang (Автор), Michael Franti (Автор), Junqing Ye (Автор), Joerg D. Hoeck (Автор), Cheng-Ran Xu (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2020-07-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Objectives: The streptozotocin (STZ) model is widely used in diabetes research. However, the cellular and molecular states of pancreatic endocrine cells in this model remain unclear. This study explored the molecular characteristics of islet cells treated with STZ and re-evaluated β-cell dysfunction...