Development of novel 9-O-substituted-13-octylberberine derivatives as potential anti-hepatocellular carcinoma agents

• Main Authors: Jichao Chen (Author), Yiping Duan (Author), Xiaoxuan Yu (Author), Jiarou Zhong (Author), Jing Bai (Author), Nian-Guang Li (Author), Zheying Zhu (Author), Jinyi Xu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel 9-O-substituted-13-octylberberine derivatives were designed, synthesised and evaluated for their anti-hepatocellular carcinoma (HCC) activities. Compound 6k showed the strongest activity against three human hepatoma cells including HepG2, Sk-Hep-1 and Huh-7 cells with IC50 values f...