ZnT8 Deficiency Protects From APAP-Induced Acute Liver Injury by Reducing Oxidative Stress Through Upregulating Hepatic Zinc and Metallothioneins

• Hoofdauteurs: Wen Su (Auteur), Mingji Feng (Auteur), Yuan Liu (Auteur), Rong Cao (Auteur), Yiao Liu (Auteur), Junyao Tang (Auteur), Ke Pan (Auteur), Rongfeng Lan (Auteur), Zhuo Mao (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Zinc transporter 8 (ZnT8) is an important zinc transporter highly expressed in pancreatic islets. Deficiency of ZnT8 leads to a marked decrease in islet zinc, which is thought to prevent liver diseases associated with oxidative stress. Herein, we aimed to investigate whether loss of islet zinc affec...