A Simple and Rapid UPLC‐UV Method for Detecting DPD Deficiency in Patients With Cancer

• Main Authors: Clémence Marin (Author), Anis Krache (Author), Chloé Palmaro (Author), Mathilde Lucas (Author), Valentin Hilaire (Author), Renée Ugdonne (Author), Bénédicte De Victor (Author), Sylvie Quaranta (Author), Caroline Solas (Author), Bruno Lacarelle (Author), Joseph Ciccolini (Author)
• Format: Book
• Published: Wiley, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Detecting patients with dihydropyrimidine dehydrogenase (DPD) deficiency is becoming a major concern in clinical oncology. Monitoring physiologic plasma uracil and/or plasma uracil‐to‐dihydrouracil metabolic ratio is a common surrogate frequently used to determine DPD phenotype without direct measur...