Effect of methotrexate and doxorubicin cumulative doses on superoxide dismutase levels in childhood acute lymphoblastic leukemia

• Main Authors: Khalida Fetriyani Ningsih (Author), Sri Mulatsih (Author), Sasmito Nugroho (Author)
• Format: Bog
• Udgivet: Indonesian Pediatric Society Publishing House, 2015-10-01T00:00:00Z.
• Fag: article
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Background Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Chemotherapeutic drugs for ALL such as methotrexate (Mtx) and doxorubicin produce reactive oxygen species (ROS), a type of free radical. The ROS can reduce levels of antioxidants in the body, including superoxid...