Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats

• Main Authors: Nobuhiro Kanazawa (Author), Masayuki Iyoda (Author), Shohei Tachibana (Author), Kei Matsumoto (Author), Yukihiro Wada (Author), Taihei Suzuki (Author), Ken Iseri (Author), Takanori Shibata (Author)
• Format: Book
• Published: Karger Publishers, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Recombinant human soluble thrombomodulin (rhTM) was approved in 2008 and has been used for treatment of disseminated intravascular coagulation in Japan. The antifibrotic effects of rhTM in acute exacerbation of idiopathic pulmonary fibrosis are well established, but the therapeutic poten...