Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling

• Main Authors: Masaki Moriyama (Author), Mitsuhiro Konno (Author), Kanako Serizawa (Author), Natsumi Yuzawa (Author), Yuki Majima (Author), Ikuo Hayashi (Author), Tomohiko Suzuki (Author), Mie Kainoh (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice. In this study, to evaluate effects of TLR3 inhibitors on histamine‐indep...