Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine
Intestine is responsible for the biotransformation of many orally-exposed chemicals. The constitutive androstane receptor (CAR/Nr1i3) is known to up-regulate many genes encoding drug-metabolizing enzymes and transporters (drug-processing genes/DPGs) in liver, but less is known regarding its effect i...
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Elsevier,
2016-09-01T00:00:00Z.
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