An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice

• Main Authors: Man-Chun Ting (Author), Chun-Peng Liao (Author), Chunli Yan (Author), Li Jia (Author), Susan Groshen (Author), Baruch Frenkel (Author), Pradip Roy-Burman (Author), Gerhard A. Coetzee (Author), Robert Maxson (Author)
• Format: Book
• Published: The Company of Biologists, 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Regions in the 8q24 gene desert contribute significantly to the risk of prostate cancer and other adult cancers. This region contains several DNA regions with enhancer activity in cultured cells. One such segment, histone acetylation peak 10 (AcP10), contains a risk single nucleotide polymor...