Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX

• Main Authors: Koji Wakui (Author), Toru Yoshitomi (Author), Akane Yamaguchi (Author), Maho Tsuchida (Author), Shingo Saito (Author), Masami Shibukawa (Author), Hitoshi Furusho (Author), Keitaro Yoshimoto (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We present a rapidly neutralizable and highly anticoagulant thrombin-binding aptamer with a short toehold sequence, originally discovered by systematic evolution of ligands by exponential enrichment (SELEX) with microbead-assisted capillary electrophoresis (MACE). MACE is a novel CE-partitioning met...