Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease

• Main Authors: Natalia Szałaj (Author), Justyna Godyń (Author), Jakub Jończyk (Author), Anna Pasieka (Author), Dawid Panek (Author), Tomasz Wichur (Author), Krzysztof Więckowski (Author), Paula Zaręba (Author), Marek Bajda (Author), Anja Pislar (Author), Barbara Malawska (Author), Raimon Sabate (Author), Anna Więckowska (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effective therapy of Alzheimer's disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands - 5-HT6 receptor antagonists and cholinesterase in...