Antioxidant Therapy Significantly Attenuates Hepatotoxicity following Low Dose Exposure to Microcystin-LR in a Murine Model of Diet-Induced Non-Alcoholic Fatty Liver Disease

• Main Authors: Apurva Lad (Author), Jonathan Hunyadi (Author), Jacob Connolly (Author), Joshua D. Breidenbach (Author), Fatimah K. Khalaf (Author), Prabhatchandra Dube (Author), Shungang Zhang (Author), Andrew L. Kleinhenz (Author), David Baliu-Rodriguez (Author), Dragan Isailovic (Author), Terry D. Hinds (Author), Cara Gatto-Weis (Author), Lauren M. Stanoszek (Author), Thomas M. Blomquist (Author), Deepak Malhotra (Author), Steven T. Haller (Author), David J. Kennedy (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously shown in a murine model of Non-alcoholic Fatty Liver Disease (NAFLD) that chronic, low-dose exposure to the Harmful Algal Bloom cyanotoxin microcystin-LR (MC-LR), resulted in significant hepatotoxicity including micro-vesicular lipid accumulation, impaired toxin metabolism as well...