Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

• Main Authors: Hadi Molanaei (Author), Abdul Rashid Qureshi (Author), Olof Heimbürger (Author), Bengt Lindholm (Author), Ulf Diczfalusy (Author), Björn Anderstam (Author), Leif Bertilsson (Author), Peter Stenvinkel (Author)
• Format: Book
• Published: BMC, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenance hemodialysis (HD). Methods A single dose of 100 mg quinine was given...