Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation

• Main Authors: Artem V. Artiukhov (Author), Anastasia V. Graf (Author), Alexey V. Kazantsev (Author), Alexandra I. Boyko (Author), Vasily A. Aleshin (Author), Alexander L. Ksenofontov (Author), Victoria I. Bunik (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Specific inhibitors of mitochondrial 2-oxoglutarate dehydrogenase (OGDH) are administered to animals to model the downregulation of the enzyme as observed in neurodegenerative diseases. Comparison of the effects of succinyl phosphonate (SP, 0.02 mmol/kg) and its uncharged precursor, triethyl succiny...