Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model

• Main Authors: Alireza Safa (Author), Allison R. Lau (Author), Sydney Aten (Author), Karl Schilling (Author), Karen L. Bales (Author), Victoria A. Miller (Author), Julie Fitzgerald (Author), Min Chen (Author), Kasey Hill (Author), Kyle Dzwigalski (Author), Karl Obrietan (Author), Mitch A. Phelps (Author), Wolfgang Sadee (Author), John Oberdick (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Newborns exposed to prenatal opioids often experience intense postnatal withdrawal after cessation of the opioid, called neonatal opioid withdrawal syndrome (NOWS), with limited pre- and postnatal therapeutic options available. In a prior study in pregnant mice we demonstrated that the peripherally...