GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49

• Main Authors: Jinhong Ren (Author), Huizhi Wei (Author), Jian Sun (Author), Xiue Feng (Author), Yuanlin Zhang (Author), Hongxia Yuan (Author), Junqiu Miao (Author), Xiaoming Qi (Author), Yuanbiao Qiao (Author), Baoguo Xiao (Author), Qingshan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Renal fibrosis is an incurable disorder characterised by an imbalance of the extracellular matrix (ECM) favouring excess production over degradation. The identification of actionable pathways and agents that promote ECM degradation to restore ECM homeostasis may help mitigate renal fibrosis. In this...