Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout

• Main Authors: Zakir Ali (Author), Fakhar ud Din (Author), Fatima Zahid (Author), Saba Sohail (Author), Basalat Imran (Author), Salman Khan (Author), Maimoona Malik (Author), Alam Zeb (Author), Gul Majid Khan (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Allopurinol (ALP), a xanthine oxidase inhibitor, is a first line drug for the treatment of gout and hyperuricemia. Being the member of BCS class II drugs, ALP has solubility problem, which affects its bioavailability. Also, ALP has shorter half-life and showed GI related problems...