Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

• Main Authors: Jessica C. McAfee (Author), Sool Lee (Author), Jiseok Lee (Author), Jessica L. Bell (Author), Oleh Krupa (Author), Jessica Davis (Author), Kimberly Insigne (Author), Marielle L. Bond (Author), Nanxiang Zhao (Author), Alan P. Boyle (Author), Douglas H. Phanstiel (Author), Michael I. Love (Author), Jason L. Stein (Author), W. Brad Ruzicka (Author), Jose Davila-Velderrain (Author), Sriram Kosuri (Author), Hyejung Won (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Genome-wide association studies (GWASs) have successfully identified 145 genomic regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging to discern causal variants. We performed a massively parallel reporter assay (MPRA) on 5,173 fine-mapped schizophre...