Extracellular Redox Regulation of α7β Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch

• Main Authors: Lukas Bergerhausen (Author), Julius Grosche (Author), Juliane Meißner (Author), Christina Hecker (Author), Michele F. Caliandro (Author), Christoph Westerhausen (Author), Andrej Kamenac (Author), Maryam Rezaei (Author), Matthias Mörgelin (Author), Gereon Poschmann (Author), Dietmar Vestweber (Author), Eva-Maria Hanschmann (Author), Johannes A. Eble (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While adhering to extracellular matrix (ECM) proteins, such as laminin-111, cells temporarily produce hydrogen peroxide at adhesion sites. To study the redox regulation of α7β1 integrin-mediated cell adhesion to laminin-111, a conserved cysteine pair within the α-subunit hinge region was replaced fo...