Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis

• Main Authors: Haneen Amawi (Author), Noor A. Hussein (Author), Charles R. Ashby (Author), Rawan Alnafisah (Author), Leticia M. Sanglard (Author), Elangovan Manivannan (Author), Chandrabose Karthikeyan (Author), Piyush Trivedi (Author), Kathryn M. Eisenmann (Author), Robert W. Robey (Author), Amit K. Tiwari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inhibition of apoptosis, disruption of cellular microtubule dynamics, and over-activation of the epithelial mesenchymal transition (EMT), are involved in the progression, metastasis, and resistance of colorectal cancer (CRC) to chemotherapy. Therefore, the design of a molecule that can target th...