Interactomic and pharmacological insights on human Sirt-1

• Main Authors: Ankush eSharma (Author), Vasu K Gautam (Author), Susan eCostantini (Author), Antonella ePaladino (Author), Giovanni eColonna (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirtuin family, in humans as well as in all mammalia, is composed by seven different homologous proteins with NAD-dependent deacetylase/ADP-ribosyltransferase activity. Numerous studies have determined their cellular location and their biological functions. In particular, Sirt-1 is defined as a nucl...