Pharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats

• Main Authors: Zhi-Yuan Zhang (Author), Hua Zhang (Author), Dan Liu (Author), Ying-Yuan Lu (Author), Xin Wang (Author), Pu Li (Author), Ya-Qing Lou (Author), Bao-Xue Yang (Author), Ya-Xin Lou (Author), Chuang Lu (Author), Qiang Zhang (Author), Guo-Liang Zhang (Author)
• Format: Book
• Published: MDPI AG, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methyl 3-amino-6-methoxythieno [2,3-b] quinoline-2-carboxylate (PU-48) is a novel diuretic urea transporter inhibitor. The aim of this study is to investigate the profile of plasma pharmacokinetics, tissue distribution, and excretion by oral dosing of PU-48 in rats. Concentrations of PU-48 within bi...