Population Pharmacokinetic/Pharmacodynamic Model-Guided Dosing Optimization of a Novel Sedative HR7056 in Chinese Healthy Subjects

• Main Authors: Ying Zhou (Author), Pei Hu (Author), Yuguang Huang (Author), Nuoer Sang (Author), Kaicheng Song (Author), Hongyun Wang (Author), Jinhua Wen (Author), Ji Jiang (Author), Xia Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HR7056 is a new benzodiazepine, showing more faster acting onset and recovery than currently available short-acting sedatives. To avoid inadequate anesthesia and predict return of cognition, allowing for immediate neurological evaluation, HR7056 pharmacokinetics and pharmacodynamics were characteriz...