Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide.

• Main Authors: Mohammad Murshid Alam (Author), Megan Kelly Bufano (Author), Peng Xu (Author), Anuj Kalsy (Author), Y Yu (Author), Y Wu Freeman (Author), Tania Sultana (Author), Md Rasheduzzaman Rashu (Author), Ishaan Desai (Author), Grace Eckhoff (Author), Daniel T Leung (Author), Richelle C Charles (Author), Regina C LaRocque (Author), Jason B Harris (Author), John D Clements (Author), Stephen B Calderwood (Author), Firdausi Qadri (Author), W F Vann (Author), Pavol Kováč (Author), Edward T Ryan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Protective immunity against cholera is serogroup specific. Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young children. METHODOLOGY:Here we report...