Unlocking the puzzle: non-defining mutations in SARS-CoV-2 proteome may affect vaccine effectiveness

• Main Authors: Eugenia Ulzurrun (Author), Ana Grande-Pérez (Author), Daniel del Hoyo (Author), Cesar Guevara (Author), Carmen Gil (Author), Carlos Oscar Sorzano (Author), Nuria E. Campillo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionSARS-CoV-2 variants are defined by specific genome-wide mutations compared to the Wuhan genome. However, non-clade-defining mutations may also impact protein structure and function, potentially leading to reduced vaccine effectiveness. Our objective is to identify mutations across the en...