A novel deep generative model for mRNA vaccine development: Designing 5' UTRs with N1-methyl-pseudouridine modification

• Main Authors: Xiaoshan Tang (Author), Miaozhe Huo (Author), Yuting Chen (Author), Hai Huang (Author), Shugang Qin (Author), Jiaqi Luo (Author), Zeyi Qin (Author), Xin Jiang (Author), Yongmei Liu (Author), Xing Duan (Author), Ruohan Wang (Author), Lingxi Chen (Author), Hao Li (Author), Na Fan (Author), Zhongshan He (Author), Xi He (Author), Bairong Shen (Author), Shuai Cheng Li (Author), Xiangrong Song (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Efficient translation mediated by the 5' untranslated region (5' UTR) is essential for the robust efficacy of mRNA vaccines. However, the N1-methyl-pseudouridine (m1Ψ) modification of mRNA can impact the translation efficiency of the 5' UTR. We discovered that the optimal 5' UTR...