Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis

• Main Authors: Xiaogang Luo (Author), Ruihua Ji (Author), Qianru Liu (Author), Xiaoxue Xiao (Author), Wengang Song (Author), Huazhang An (Author), Yingke Li (Author), Jun Zhou (Author)
• Format: Book
• Published: Karger Publishers, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cytosolic viral nucleic acid-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor interferon (IFN)-regulatory factor 3 (IRF3) to induce type I IFN production and antiviral immune responses. However, the mechanism that triggers the binding of T...