Formononetin Ameliorates Renal Dysfunction, Oxidative Stress, Inflammation, and Apoptosis and Upregulates Nrf2/HO-1 Signaling in a Rat Model of Gentamicin-Induced Nephrotoxicity

• Main Authors: Osama Y. Althunibat (Author), Mohammad H. Abukhalil (Author), Saleem H. Aladaileh (Author), Haitham Qaralleh (Author), Wesam Al-Amarat (Author), Manal A. Alfwuaires (Author), Abdulmohsen I. Algefare (Author), Nader Ibrahim Namazi (Author), Sahar J. Melebary (Author), Ahmad O. Babalghith (Author), Carlos Adam Conte-Junior (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity. Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological activities. In this study, we have assessed the nephroprotective efficacy of FN against GEN-induced renal injury in rats. Rats wer...