In Silico Prediction of New Inhibitors for Kirsten Rat Sarcoma G12D Cancer Drug Target Using Machine Learning-Based Virtual Screening, Molecular Docking, and Molecular Dynamic Simulation Approaches

• Үндсэн зохиолчид: Amar Ajmal (Зохиогч), Muhammad Danial (Зохиогч), Maryam Zulfat (Зохиогч), Muhammad Numan (Зохиогч), Sidra Zakir (Зохиогч), Chandni Hayat (Зохиогч), Khulood Fahad Alabbosh (Зохиогч), Magdi E. A. Zaki (Зохиогч), Arif Ali (Зохиогч), Dongqing Wei (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2024-04-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Single-point mutations in the Kirsten rat sarcoma (KRAS) viral proto-oncogene are the most common cause of human cancer. In humans, oncogenic KRAS mutations are responsible for about 30% of lung, pancreatic, and colon cancers. One of the predominant mutant KRAS G12D variants is responsible for pancr...