SETD2 non genomic loss of function in advanced systemic mastocytosis is mediated by an Aurora kinase A/MDM2 axis and can be therapeutically targeted

• Главные авторы: Manuela Mancini (Автор), Cecilia Monaldi (Автор), Sara De Santis (Автор), Cristina Papayannidis (Автор), Michela Rondoni (Автор), Chiara Sartor (Автор), Samantha Bruno (Автор), Livio Pagano (Автор), Marianna Criscuolo (Автор), Roberta Zanotti (Автор), Massimiliano Bonifacio (Автор), Patrizia Tosi (Автор), Michel Arock (Автор), Peter Valent (Автор), Michele Cavo (Автор), Simona Soverini (Автор)
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• Опубликовано: BMC, 2023-03-01T00:00:00Z.
• Предметы: article
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Abstract Background The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3). SETD2 loss of function has been observed in solid and hematologic malignancies. We have recently...