Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder

• Main Authors: D. Iezzi (Author), L. Curti (Author), G. Ranieri (Author), E. Gerace (Author), A. Costa (Author), A. Ilari (Author), A. La Rocca (Author), C. Luceri (Author), M. D'Ambrosio (Author), L. Silvestri (Author), M. Scardigli (Author), G. Mannaioni (Author), A. Masi (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium spiny neurons (MSNs) of ado...