Effect of Efonidipine on TGF-β1-Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts

• Main Authors: Bai Lei (Author), Hirofumi Hitomi (Author), Tatsuhiko Mori (Author), Yukiko Nagai (Author), Kazushi Deguchi (Author), Hirohito Mori (Author), Tsutomu Masaki (Author), Daisuke Nakano (Author), Hiroyuki Kobori (Author), Yasushi Kitaura (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Transforming growth factor beta-1 (TGF-β1) plays a critical role in progression of cardiac fibrosis, which may involve intracellular calcium change. We examined effects of efonidipine, a dual T-type and L-type calcium channel blocker (CCB), on TGF-β1-induced fibrotic changes in neonatal r...