ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway

• Main Authors: Huanlong Liu (Author), Zhenhua Pan (Author), Xindi Ma (Author), Junru Cui (Author), Juan Gao (Author), Qingfeng Miao (Author), Zhongning Zhu (Author), Xueyan Chen (Author), Suwen Su (Author)
• Format: Book
• Published: BMC, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Inflammation plays a major role in the pulmonary artery hypertension (PAH) and the acute lung injury (ALI) diseases. The common feature of these complications is the dysfunction of pulmonary microvascular endothelial cells (PMVECs). Fasudil, the only Rho kinase (ROCK) inhibitor u...