Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity

• Үндсэн зохиолчид: Katharinne Ingrid Moraes Carvalho (Зохиогч), Diego de Sá Coutinho (Зохиогч), Humberto Cavalcante Joca (Зохиогч), Artur Santos Miranda (Зохиогч), Jader dos Santos Cruz (Зохиогч), Emerson Teixeira Silva (Зохиогч), Marcus Vinícius Nora Souza (Зохиогч), Robson Xavier Faria (Зохиогч), Patricia Machado Rodrigues e Silva (Зохиогч), Jorge Carlos Santos Costa (Зохиогч), Marco Aurélio Martins (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Local anesthetics (LAs), such as lidocaine and mexiletine, inhibit bronchoconstriction in asthmatics, but adverse effects limit their use for this specific clinical application. In this study, we describe the anti-spasmodic properties of the mexiletine analog 2-(2-aminopropoxy)-3,5-dimethyl, 4-Br-be...