Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?

• Main Authors: Mattia Di Nunzio (Author), Veronica Valli (Author), Lidia Tomás-Cobos (Author), Teresa Tomás-Chisbert (Author), Lucía Murgui-Bosch (Author), Francesca Danesi (Author), Alessandra Bordoni (Author)
• Format: Book
• Published: BMC, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is often used to select the most promising molecules to be studied in vivo....