Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.

• Main Authors: Noëlle Louise O'Regan (Author), Svenja Steinfelder (Author), Gopinath Venugopal (Author), Gopala B Rao (Author), Richard Lucius (Author), Aparna Srikantam (Author), Susanne Hartmann (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monocytes and macrophages contribute to the dysfunction of immune responses in human filariasis. During patent infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive.To determine whether bl...