Pharmacological Activation of SIRT3 Modulates the Response of Cancer Cells to Acidic pH

• Main Authors: Michele Aventaggiato (Author), Tania Arcangeli (Author), Enza Vernucci (Author), Federica Barreca (Author), Luigi Sansone (Author), Laura Pellegrini (Author), Elena Pontemezzo (Author), Sergio Valente (Author), Rossella Fioravanti (Author), Matteo Antonio Russo (Author), Antonello Mai (Author), Marco Tafani (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells modulate their metabolism, creating an acidic microenvironment that, in turn, can favor tumor progression and chemotherapy resistance. Tumor cells adopt strategies to survive a drop in extracellular pH (pHe). In the present manuscript, we investigated the contribution of mitochondrial s...