Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells

• मुख्य लेखकों: Yaoyu Chen (लेखक), Margaret Favata (लेखक), Michelle Pusey (लेखक), Jun Li (लेखक), Yvonne Lo (लेखक), Min Ye (लेखक), Richard Wynn (लेखक), Xiaozhao Wang (लेखक), Wenqing Yao (लेखक), Yingnan Chen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2020-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest-specific protein 6 (GAS6)-induced MER phosphorylation is often unstable and difficult to detect without pervanadate pretreatment in human cancer cells, posing a challenge for th...