Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells

• Main Authors: Yaoyu Chen (Author), Margaret Favata (Author), Michelle Pusey (Author), Jun Li (Author), Yvonne Lo (Author), Min Ye (Author), Richard Wynn (Author), Xiaozhao Wang (Author), Wenqing Yao (Author), Yingnan Chen (Author)
• Format: Book
• Published: BMC, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest-specific protein 6 (GAS6)-induced MER phosphorylation is often unstable and difficult to detect without pervanadate pretreatment in human cancer cells, posing a challenge for th...