A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation

• Main Authors: Carolina Pellegrini (Author), Matteo Fornai (Author), Rocchina Colucci (Author), Laura Benvenuti (Author), Vanessa D'Antongiovanni (Author), Gianfranco Natale (Author), Federica Fulceri (Author), Marta Giorgis (Author), Elisabetta Marini (Author), Simone Gastaldi (Author), Massimo Bertinaria (Author), Corrado Blandizzi (Author), Luca Antonioli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is pivotal in maintaining intestinal homeostasis and sustaining enteric immune responses in the setting of inflammatory bowel diseases. Drugs acting as NLRP3 blockers could repres...